Depression is currently among the four major diseases affecting the world population and is linked to high rates of impairment and mortality, and can be defined as a disorder with heterogeneous biological bases with a chance of affecting 10% -30% of women and 7% -15% of men throughout their lives.
Clinical and preclinical studies suggest that the expression of brain-derived neurotrophic factor (BNDF) may be involved in behavioral events related to depression and that modulation of these neurotrophins will also mediate antidepressant effects. bdnf elisa kit is also very helpful to researchers.
BDNF is the most important neurotrophin in the human brain and plays an important role in the development and defense of the central nervous system as well as in the regulation of synapses, learning, and memory.
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BDNF contributes extensively to neuroplasticity in the human brain, namely axonal and dendritic growth and remodeling, neuron differentiation, synaptic growth and transmission, neurotransmitter modulation, and long-term potentiation.
One of the main functions of BDNF is to promote the development and stability of neural connections, as the hippocampus is an important site for its action. It is known that BDNF is required for the proper development and survival of GABAergic neurons, cholinergic and serotonergic antidepressants.
There has been speculation about a link between BDNF, sleep, and depression. The low neurotrophic activity was associated with decreased cell numbers in the prefrontal cortex, amygdala, and decreased hippocampal size, suggesting that BDNF may play an important role in the development of depression.
Several authors have suggested that BDNF has a potential role in the pathology and treatment of many psychiatric disorders. Studies show low levels of BDNF in people with non-drug depression, but no association with disease severity.
The BDNF gene is an important candidate in finding the mechanism of action of antidepressants because BDNF plays an important role in the function of the serotonergic system.